Shoc2 uniprot

Author: kcsi

August undefined, 2024

Web29 Sep 2024 · Assembly of the SHOC2–MRAS–PP1CA complex. We purified the pre-assembled human SMP complex by co-expressing SHOC2, MRAS (MRAS-Q71L or wild type (WT)), and PP1CA from a single plasmid (Fig. 1a ... WebSHOC2-003: 815: No protein- Gene/transcript that doesn't contain an open reading frame (ORF). Processed transcript---ENST00000489783.1: SHOC2-004: 749: ... Uniprot. This transcript corresponds to the following Uniprot identifiers: Q9UQ13. CCDS. This transcript is a member of the Human CCDS set: CCDS7568. Version. ENST00000369452.4.

UniProt

WebKIAA0862. Sequence Length (AA) Molecular Weight (Da) 582. 64888. Protein Name. Leucine-rich repeat protein SHOC-2. Sources. UniProt. WebDephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at … map of brentwood and franklin tn

Search: SHOC2 - The Human Protein Atlas

WebThe corresponding start and end position are showed above each domain (Uniprot: Q06124) while the distribution of the mutations in Brazilian patients are listed underneath. The mutations are colored differently: black for variants found in another Brazilian cohort, 11 red for variants found in the present study, and purple for variants found in both studies. WebSHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. ... Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa Uncharacterized bands may appear in some lysate(s). WebSHOC2 Approved name SHOC2 leucine rich repeat scaffold protein Locus type gene with protein product HGNC ID HGNC:15454 Symbol status Approved Previous names soc-2 (suppressor of clear, C.elegans) homolog soc-2 suppressor of clear homolog (C. elegans) SHOC2 leucine-rich repeat scaffold protein SHOC2, leucine rich repeat scaffold protein map of bressay

Anti-SHOC2 Antibody ABS461 - EMD Millipore

SHOC2 Gene - GeneCards SHOC2 Protein SHOC2 Antibody

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high … WebSHOC2 10:110919367-111017307. Forward strand gene: SHOC2 leucine rich repeat scaffold protein Also known as: SUR8, SOC-2, SUR-8, SOC2, KIAA0862, ... Show more Source: UniProt. DECIPHER holds 10 sequence variants in this gene, in 10 open-access patients Overview map of bretagne franceWebWelcome to ProteomicsDB! ProteomicsDB is an effort of the Technische Universität München (TUM). It is dedicated to expedite the identification of the human proteome and its use across the scientific community. map of bretherton

"WebSymbol Description Category UniProt ID GIFtS GC id Score; 126: NPHS2: NPHS2 Stomatin Family Member, Podocin: Protein Coding: Q9NP85: 49: GC01M179554: 58.05: 127: AIRE ... " - Shoc2 uniprot

Shoc2 uniprot

Web4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and … Web10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ...

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Web17561-1-AP targets Sur-8 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. WebDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. - Find MSDS or SDS, a COA, data sheets and more information. ... UniProt Number: Q9UQ13; Molecular Weight ~65 kDa observed. Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa. Uncharacterized bands ...

WebRCSB. monomer. 88-581. 1× MG; Assess. Structure of the human leucine rich repeat protein SHOC2, residues 80-582. 7tyg. WebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s …

WebSubcellular - SHOC2 - The Human Protein Atlas SUMMARY TISSUE BRAIN SINGLE CELL TISSUE CELL PATHOLOGY DISEASE IMMUNE BLOOD SUBCELL CELL LINE SHOC2 SUBCELLULAR RNA EXPRESSION HUMAN CELLS MOUSE CELLS ANTIBODIES AND VALIDATION Dictionary Cytosol Nucleoplasm Subcellular proteome Cytosol Nucleoplasm Web13 Jul 2024 · SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes 2, 3, 4, 5. However, the structure and...

WebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s …

Web5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … kristin ess copper hair glossWeb14 Dec 2024 · The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the … map of bretonniaWebAll lanes : Anti-Shoc2 / Sur8 antibody (ab229805) at 1/500 dilution Lane 1 : MCF7 (human breast adenocarcinoma cell line) whole cell lysate Lane 2 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate Lane 3 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate Secondary All lanes : Goat polyclonal to rabbit IgG at … map of brevoyWebResearch studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K/Akt signaling axis through its interaction with the ... map of bretton woods new hampshireWebSHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. map of brevard county parksWeb1 Apr 2006 · Shoc2 function is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of Shoc2 expression inhibits MAPK, but not PI3K activity. We propose that the Shoc2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Full text links map of brewarrinaWeb29 Sep 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13 , but the structure of SHOC2 and the … kristin ess ceramic curling iron