WebHenik R A, Kellum H B, Bentjen S A et al (2006) Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation. JVIM 20 (2), 415-417 PubMed. Neff M W, Robertson K R, Wong A K et al (2004) Breed distribution and history of canine mdr1-1delta a pharmacogenetics mutation that marks the emergence of breeds from the collie lineage. WebMDR1 is a mutation in the genetic makeup of the dog which causes problems in the dogs' ability to remove certain drugs from the brain to avoid toxicity even at 'normal' doses for the drug. MDR1 affects a great number of herding breeds including the Collie. The mutation in Collies is identified as either normal/normal (no genetic mutation ...
Collie Dog Breed Information - American Kennel Club
WebMar 6, 2014 · Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies. Sixteen Collies homozygous for … WebAug 2, 2004 · The mdr1-1Δ allele that was discovered in the Collie breed has since been found in three Australian Shepherd dogs, one of which presented clinically with ivermectin neurotoxicity ().Australian Shepherds are believed to share common ancestry with Collies, suggesting that mdr1-1Δ might stem from a single ancestral mutation that has been … karen chernoff dermatology
MDR1 – Collie Health Foundation
WebHealth Test: MDR1* Description: Sensitivity to certain drugs, including ivermectin, which can cause severe reactions or death in some collies. Only use this test for Collies who are … WebThe MDR1 variant was originally identified in association with ivermectin sensitivity in Collies but has since been identified in several other breeds as well as mixed breed … WebLe dossier MDR1 de Collie online reconnu par les professionnels de santé animale lors du congrès annuel organisé à Paris du 5 au 7 avril 2013 par l'AFVAC (Association française … Le dossier MDR1 de Collie online reconnu par les professionnels de santé animale … karen chesleigh douglas elliman